MT1 specifications and molecular characteristics
The technical specification for Melanotan I, the MT1 research material supplied by MT1 Peptide Co.: molecular formula C78H111N21O19, average molecular weight 1646.85 g/mol, 13 residues, supplied as a lyophilized powder. Each item is explained below.
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Specification table
| Product | Melanotan I |
|---|---|
| Type | Synthetic linear α-MSH analog (13 residues) |
| Molecular formula | C78H111N21O19 |
| Molecular weight | 1646.85 g/mol (average) |
| Length | 13 residues |
| Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| N-terminus | Acetyl (Ac-Ser1) |
| C-terminus | Amide (Val13-NH2) |
| Non-standard residues | Nle4, D-Phe7 |
| Receptor design | Melanocortin 1 receptor (MC1R) |
| Form | Lyophilized powder |
| Vial sizes | 10 mg |
| Purity specification | ≥95% (HPLC-UV) |
| Purity, current lots | 97.55% |
| Identity specification | Confirmed by HPLC retention-time match |
| Testing laboratory | ILS Laboratories (independent) |
| Storage | Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. |
| Designation | Research use only |
Current lot results against specification
Every current lot meets the release specification. Current lots test at 97.55% by HPLC-UV against a specification of ≥95%, and identity is confirmed by HPLC retention-time match on every lot.
MT1 molecular formula
The molecular formula of Melanotan I is C78H111N21O19. Includes the N-terminal acetyl group and C-terminal amide.
MT1 molecular weight
The average molecular weight of Melanotan I is 1646.85 g/mol. "Average" means it is calculated from natural isotope abundances.
MT1 sequence
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Structure and modifications
MT1 is linear, with an acetylated N-terminus (Ac-Ser1) and amidated C-terminus (Val13-NH2). Position 4 is norleucine (Nle) and position 7 is D-phenylalanine. The central His-D-Phe-Arg-Trp segment is the core shared by melanocortin receptor ligands. The single tryptophan (Trp9) is its most oxidation-sensitive residue.
Receptor classification
Melanotan I is designed for activity at the melanocortin 1 receptor (MC1R).
Physical form
Lyophilized powder, recorded as the appearance on every certificate. Lyophilization (freeze-drying) removes water, which slows most chemical degradation. What lyophilized means.
Purity and identity specifications
MT1 Peptide Co.’s stated release specification is ≥95% HPLC-UV purity with identity confirmed by HPLC retention-time match against a reference standard. The current lot, KB-34289, reported 97.55%. How purity is measured, or how specifications fit into the quality and supply-chain process.
Analytical and testing methods
HPLC-UV for purity, HPLC-RTM for identity and laboratory quantitation for net content, performed on every lot by ILS Laboratories. Each lot is also screened for fentanyl by immunoassay. LAL endotoxin testing (USP <85>) and PCR microbial screening are reported for lots where they were run. Testing and quality control.
Research designation
Melanotan I is designated research use only: supplied for laboratory research by qualified personnel. Research use only policy.
Buy MT1
10 mg vials. Current lot KB-34289 tested at 97.55% purity with identity confirmed by HPLC retention-time match against a reference standard. Current purchasing is available through Klow.bio.